A nonparametric Bayesian continual reassessment method in single-agent dose-finding studies

Abstract Background The main purpose of dose-finding studies in Phase I trial is to estimate maximum tolerated dose (MTD), which is the maximum test dose that can be assigned with an acceptable level of toxicity. Existing methods developed for single-agent dose-finding assume that the dose-toxicity...

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Hlavní autoři:	Niansheng Tang, Songjian Wang, Gen Ye
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2018-12-01
Edice:	BMC Medical Research Methodology
Témata:	Adaptive rejection Metropolis sampling algorithm Continual reassessment method Dirichlet process prior Dose-finding design Gibbs sampler Maximum tolerated dose
On-line přístup:	http://link.springer.com/article/10.1186/s12874-018-0604-9
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