A nonparametric Bayesian continual reassessment method in single-agent dose-finding studies
Abstract Background The main purpose of dose-finding studies in Phase I trial is to estimate maximum tolerated dose (MTD), which is the maximum test dose that can be assigned with an acceptable level of toxicity. Existing methods developed for single-agent dose-finding assume that the dose-toxicity...
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| Principais autores: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2018-12-01
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| coleção: | BMC Medical Research Methodology |
| Assuntos: | |
| Acesso em linha: | http://link.springer.com/article/10.1186/s12874-018-0604-9 |
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