Identification of novel potent peptide inhibitors targeting the polo-box domain of PLK1: structure-based pharmacophore modelling, virtual screening, molecular docking, molecular dynamics study and biological evaluation

Multiple myeloma, a hematological malignancy, shows PLK1 overexpression in cells correlates with poor prognosis, suggesting PLK1 as a potential therapeutic target. In this study, we discovered five peptides (PLs 1–5) targeting the polo box domain (PBD) of PLK1 through an integrated virtual screening...

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Bibliografische Detailangaben

Hauptverfasser:	Hong Zhou, Lixia Guan, Guoqiang Lin, Xiaotian Yang, Xingxia Zhang, Yejun Si, Yanming Zhang, Juan Chen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis Group 2025-12-01
Schriftenreihe:	Journal of Enzyme Inhibition and Medicinal Chemistry
Schlagworte:	Multiple myeloma polo-like kinase 1 (PLK1) polo box domain (PBD) structure-based virtual screening
Online-Zugang:	https://www.tandfonline.com/doi/10.1080/14756366.2025.2563601
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