Identification of novel potent peptide inhibitors targeting the polo-box domain of PLK1: structure-based pharmacophore modelling, virtual screening, molecular docking, molecular dynamics study and biological evaluation
Multiple myeloma, a hematological malignancy, shows PLK1 overexpression in cells correlates with poor prognosis, suggesting PLK1 as a potential therapeutic target. In this study, we discovered five peptides (PLs 1–5) targeting the polo box domain (PBD) of PLK1 through an integrated virtual screening...
Sparad:
| Huvudupphov: | , , , , , , , |
|---|---|
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
Taylor & Francis Group
2025-12-01
|
| Serie: | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Ämnen: | |
| Länkar: | https://www.tandfonline.com/doi/10.1080/14756366.2025.2563601 |
| Taggar: |
Inga taggar, Lägg till första taggen!
|