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Generation of functional dopaminergic neurons from human spermatogonial stem cells to rescue parkinsonian phenotypes

Abstract Background Recent progress in the induced generation of dopaminergic (DA) neurons from different types of stem cells or reprogrammed somatic cells holds tremendous potential for the treatment of Parkinson’s disease (PD). However, the lack of a reliable source for cell replacement therapy re...

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Principais autores: Hao Yang, Dingjun Hao, Cheng Liu, Dageng Huang, Bo Chen, Hong Fan, Cuicui Liu, Lingling Zhang, Qian Zhang, Jing An, Jingjing Zhao
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2019-06-01
Serier:Stem Cell Research & Therapy
Fag:
Human spermatogonial stem cells
Direct conversion
Dopaminergic neurons
Neurophysiology activity, cell transplantation
Parkinson’s disease
Online adgang:http://link.springer.com/article/10.1186/s13287-019-1294-x
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