Generation of functional dopaminergic neurons from human spermatogonial stem cells to rescue parkinsonian phenotypes

Abstract Background Recent progress in the induced generation of dopaminergic (DA) neurons from different types of stem cells or reprogrammed somatic cells holds tremendous potential for the treatment of Parkinson’s disease (PD). However, the lack of a reliable source for cell replacement therapy re...

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Hlavní autoři:	Hao Yang, Dingjun Hao, Cheng Liu, Dageng Huang, Bo Chen, Hong Fan, Cuicui Liu, Lingling Zhang, Qian Zhang, Jing An, Jingjing Zhao
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2019-06-01
Edice:	Stem Cell Research & Therapy
Témata:	Human spermatogonial stem cells Direct conversion Dopaminergic neurons Neurophysiology activity, cell transplantation Parkinson’s disease
On-line přístup:	http://link.springer.com/article/10.1186/s13287-019-1294-x
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