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The Valproate Mediates Radio-Bidirectional Regulation Through RFWD3-Dependent Ubiquitination on Rad51

Ionizing radiation (IR) can induce DNA double-strand breaks (DSBs) in tumor cells during radiotherapy (RT), but the efficiency of RT is limited because of the toxicity to normal cells. Locating an adjuvant treatment to alleviate damage in normal cells while sensitizing tumor cells to IR has attracte...

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Principais autores: Guochao Liu, David Lim, Zuchao Cai, Wenwen Ding, Zhujun Tian, Chao Dong, Fengmei Zhang, Gongshe Guo, Xiaowei Wang, Pingkun Zhou, Zhihui Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-03-01
coleção:Frontiers in Oncology
Assuntos:
valproate
radiosensitization
radioprotection
ubiquitination
RFWD3
Rad51
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2021.646256/full
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