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The Valproate Mediates Radio-Bidirectional Regulation Through RFWD3-Dependent Ubiquitination on Rad51

Ionizing radiation (IR) can induce DNA double-strand breaks (DSBs) in tumor cells during radiotherapy (RT), but the efficiency of RT is limited because of the toxicity to normal cells. Locating an adjuvant treatment to alleviate damage in normal cells while sensitizing tumor cells to IR has attracte...

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Hlavní autoři: Guochao Liu, David Lim, Zuchao Cai, Wenwen Ding, Zhujun Tian, Chao Dong, Fengmei Zhang, Gongshe Guo, Xiaowei Wang, Pingkun Zhou, Zhihui Feng
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021-03-01
Edice:Frontiers in Oncology
Témata:
valproate
radiosensitization
radioprotection
ubiquitination
RFWD3
Rad51
On-line přístup:https://www.frontiersin.org/articles/10.3389/fonc.2021.646256/full
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