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RFWD3 Reprograms Nucleotide Metabolism Through PHGDH to Induce Chemoresistance In Osteosarcoma

Abstract Chemoresistance represents a major challenge for osteosarcoma treatment. Despite the improved knowledge of cancer biology, the core determinants of cisplatin (DDP) resistance in osteosarcoma remain unclear and deserve further exploration. Here, RFWD3 is identified as a key regulator of DDP...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Wenchao Zhang, Chi Yin, Lin Qi, Zhongyue Liu, Ruiling Xu, Chao Tu, Zhihong Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wiley 2025-04-01
Schriftenreihe:Advanced Science
Schlagworte:
chemoresistance
cisplatin
nucleotide metabolism
osteosarcoma
RFWD3
Online-Zugang:https://doi.org/10.1002/advs.202410937
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