Modulation of Apoptotic Cell Death and Neuroprotective Effects of Glutathione—L-Dopa Codrug Against H₂O₂-Induced Cellular Toxicity

The L-3,4-dihydroxyphenylalanine (LD) is the gold standard drug currently used to manage Parkinson’s disease (PD) and to control its symptoms. However, LD could cause disease neurotoxicity due to the generation of pro-oxidant intermediates deriving from its autoxidation. In order to overcome t...

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Autori principali:	Sara Franceschelli, Paola Lanuti, Alessio Ferrone, Daniela Maria Pia Gatta, Lorenza Speranza, Mirko Pesce, Alfredo Grilli, Ivana Cacciatore, Emanuela Ricciotti, Antonio Di Stefano, Sebastiano Miscia, Mario Felaco, Antonia Patruno
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2019-08-01
Serie:	Antioxidants
Soggetti:	L-Dopa glutathione SH-SY5Y cell line U-937 cell line Parkinson’s disease ROS apoptosis
Accesso online:	https://www.mdpi.com/2076-3921/8/8/319
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