Modulation of Apoptotic Cell Death and Neuroprotective Effects of Glutathione—L-Dopa Codrug Against H₂O₂-Induced Cellular Toxicity

The L-3,4-dihydroxyphenylalanine (LD) is the gold standard drug currently used to manage Parkinson’s disease (PD) and to control its symptoms. However, LD could cause disease neurotoxicity due to the generation of pro-oxidant intermediates deriving from its autoxidation. In order to overcome t...

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Principais autores:	Sara Franceschelli, Paola Lanuti, Alessio Ferrone, Daniela Maria Pia Gatta, Lorenza Speranza, Mirko Pesce, Alfredo Grilli, Ivana Cacciatore, Emanuela Ricciotti, Antonio Di Stefano, Sebastiano Miscia, Mario Felaco, Antonia Patruno
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2019-08-01
Series:	Antioxidants
Assuntos:	L-Dopa glutathione SH-SY5Y cell line U-937 cell line Parkinson’s disease ROS apoptosis
Acceso en liña:	https://www.mdpi.com/2076-3921/8/8/319
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