A cyclin-dependent kinase-mediated phosphorylation switch of disordered protein condensation

Abstract Cell cycle transitions result from global changes in protein phosphorylation states triggered by cyclin-dependent kinases (CDKs). To understand how this complexity produces an ordered and rapid cellular reorganisation, we generated a high-resolution map of changing phosphosites throughout u...

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Hlavní autoři:	Juan Manuel Valverde, Geronimo Dubra, Michael Phillips, Austin Haider, Carlos Elena-Real, Aurélie Fournet, Emile Alghoul, Dhanvantri Chahar, Nuria Andrés-Sanchez, Matteo Paloni, Pau Bernadó, Guido van Mierlo, Michiel Vermeulen, Henk van den Toorn, Albert J. R. Heck, Angelos Constantinou, Alessandro Barducci, Kingshuk Ghosh, Nathalie Sibille, Puck Knipscheer, Liliana Krasinska, Daniel Fisher, Maarten Altelaar
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2023-10-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-023-42049-0
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