Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A

An important question in the cell cycle field is how cyclin-dependent kinases (cdks) target their substrates. We have studied the role of a conserved hydrophobic patch on the surface of cyclin A in substrate recognition by cyclin A-cdk2. This hydrophobic patch is ≈35Å away from the active site of cd...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Schulman, Brenda A., Lindstrom, Derek L., Harlow, Ed
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1998
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27915/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9724724/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.18.10453
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