Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A
An important question in the cell cycle field is how cyclin-dependent kinases (cdks) target their substrates. We have studied the role of a conserved hydrophobic patch on the surface of cyclin A in substrate recognition by cyclin A-cdk2. This hydrophobic patch is ≈35Å away from the active site of cd...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27915/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9724724/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.18.10453 |
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