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Magnesium ions facilitate osteogenic differentiation and intervertebral fusion via m6A methylation of RhoA mRNA

Background: Magnesium-based implants facilitate bone regeneration via degradation. However, the epigenetic mechanisms, particularly N6-methyladenosine (m6A) modification regulated by Mg2+, remain incompletely understood. This study investigated the role of Mg2+ in osteogenic differentiation through...

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Principais autores: Haocheng Xu, Linli Li, Fan Zhang, Minghao Shao, Chenyan Li, Yitong Xue, Dachuan Li, Zhidi Lin, Zhaoyang Gong, Jiongdong Wu, Zhiwen Luo, Zhicai Shi, Xinlei Xia, Hongli Wang, Xiaosheng Ma, Jianyuan Jiang, Xiaochuan Gu, Yang Liu, Xiao Lu, Feizhou Lyu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2026-03-01
coleção:Journal of Orthopaedic Translation
Assuntos:
Intervertebral fusion
Magnesium ions
METTL3
m6A modification
Osteogenic differentiation
RhoA/ROCK pathway
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2214031X26000112
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