Targeting glucocorticoid receptor to enhance immunotherapy response in triple negative breast cancer

Abstract Background Immune checkpoint blockade (ICB) therapies for triple negative breast cancer (TNBC) have yielded limited clinical benefits, which may be attributed to the immunosuppressive tumor immune microenvironment (TIME). Glucocorticoid receptor (GR) has long been thought to suppress immuni...

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Autori principali:	Lei Yang, Zhenzhou Chen, Yajun Chen, Jian Yang, Shengchun Liu, Kun Deng, Jianping Xu, Ming Cui, Zhongxue Fu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2026-01-01
Serie:	Breast Cancer Research
Soggetti:	Triple negative breast cancer Glucocorticoid receptor Immune checkpoint blockade Immunotherapy Tumor immune microenvironment
Accesso online:	https://doi.org/10.1186/s13058-026-02230-x
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