Targeting glucocorticoid receptor to enhance immunotherapy response in triple negative breast cancer

Abstract Background Immune checkpoint blockade (ICB) therapies for triple negative breast cancer (TNBC) have yielded limited clinical benefits, which may be attributed to the immunosuppressive tumor immune microenvironment (TIME). Glucocorticoid receptor (GR) has long been thought to suppress immuni...

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主要な著者:	Lei Yang, Zhenzhou Chen, Yajun Chen, Jian Yang, Shengchun Liu, Kun Deng, Jianping Xu, Ming Cui, Zhongxue Fu
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2026-01-01
シリーズ:	Breast Cancer Research
主題:	Triple negative breast cancer Glucocorticoid receptor Immune checkpoint blockade Immunotherapy Tumor immune microenvironment
オンライン･アクセス:	https://doi.org/10.1186/s13058-026-02230-x
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