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Targeting glucocorticoid receptor to enhance immunotherapy response in triple negative breast cancer

Abstract Background Immune checkpoint blockade (ICB) therapies for triple negative breast cancer (TNBC) have yielded limited clinical benefits, which may be attributed to the immunosuppressive tumor immune microenvironment (TIME). Glucocorticoid receptor (GR) has long been thought to suppress immuni...

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Principais autores: Lei Yang, Zhenzhou Chen, Yajun Chen, Jian Yang, Shengchun Liu, Kun Deng, Jianping Xu, Ming Cui, Zhongxue Fu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-01-01
coleção:Breast Cancer Research
Assuntos:
Triple negative breast cancer
Glucocorticoid receptor
Immune checkpoint blockade
Immunotherapy
Tumor immune microenvironment
Acesso em linha:https://doi.org/10.1186/s13058-026-02230-x
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