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Effects of low intracellular glutathione and CbrA-CbrB-Crc signaling on methylglyoxal sensitivity in Pseudomonas aeruginosa LasR-deficient mutants

ABSTRACT Pseudomonas aeruginosa, which causes many types of infections, often has loss-of-function mutations in the gene encoding LasR, a transcription factor involved in quorum sensing. Here, we report that LasR− strains are more sensitive to the electrophile methylglyoxal (MGO), which is produced...

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Autores principales: Ana Altamirano, Marina Ruzic, Anna E. Cryan, Deborah A. Hogan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2025-10-01
Colección:Journal of Bacteriology
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Acceso en línea:https://journals.asm.org/doi/10.1128/jb.00394-24
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