Dysregulation of the DNA damage response by phosphorothioate antisense oligonucleotides

Abstract Phosphorothioate (PS)-modified antisense oligonucleotides (ASOs) are widely used to modulate gene expression in basic research and therapy. Within cells, these ASOs seed nuclear structures with unclear functions and consequences. At DNA breaks, endogenous nucleotide polymers drive the assem...

Full beskrivning

Bibliografiska uppgifter

Huvudupphov:	Linn Hjelmgren, Qianyu Zhou, Sandro Schmidli, Manon Gloudemans, Tomasz Czapik, Samantha Roudi, Malgorzata Honcharenko, Daniel W. Hagey, Samir EL Andaloussi, Marianne Farnebo
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Nature Portfolio 2026-02-01
Serie:	Nature Communications
Länkar:	https://doi.org/10.1038/s41467-026-69980-2
Taggar:	Lägg till en tagg Inga taggar, Lägg till första taggen!