Dysregulation of the DNA damage response by phosphorothioate antisense oligonucleotides

Abstract Phosphorothioate (PS)-modified antisense oligonucleotides (ASOs) are widely used to modulate gene expression in basic research and therapy. Within cells, these ASOs seed nuclear structures with unclear functions and consequences. At DNA breaks, endogenous nucleotide polymers drive the assem...

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Autores principales:	Linn Hjelmgren, Qianyu Zhou, Sandro Schmidli, Manon Gloudemans, Tomasz Czapik, Samantha Roudi, Malgorzata Honcharenko, Daniel W. Hagey, Samir EL Andaloussi, Marianne Farnebo
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2026-02-01
Colección:	Nature Communications
Acceso en línea:	https://doi.org/10.1038/s41467-026-69980-2
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