The unfolded protein response affects readthrough of premature termination codons

Abstract One‐third of monogenic inherited diseases result from premature termination codons (PTCs). Readthrough of in‐frame PTCs enables synthesis of full‐length functional proteins. However, extended variability in the response to readthrough treatment is found among patients, which correlates with...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Yifat S Oren, Michelle L McClure, Steven M Rowe, Eric J Sorscher, Assaf C Bester, Miriam Manor, Eitan Kerem, Joseph Rivlin, Fouad Zahdeh, Matthias Mann, Tamar Geiger, Batsheva Kerem
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Springer Nature 2014-04-01
Цуврал:	EMBO Molecular Medicine
Нөхцлүүд:	nonsense‐mediated mRNA decay premature termination codon readthrough treatment unfolded protein response
Онлайн хандалт:	https://doi.org/10.1002/emmm.201303347
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!