A Simple and Affordable Method to Create Nonsense Mutation Clones of p53 for Studying the Premature Termination Codon Readthrough Activity of PTC124

(1) Background: A premature termination codon (PTC) can be induced by a type of point mutation known as a nonsense mutation, which occurs within the coding region. Approximately 3.8% of human cancer patients have nonsense mutations of p53. However, the non-aminoglycoside drug PTC124 has shown potent...

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Главные авторы:	Chia-Chi Chen, Ruo-Yu Liao, Fang-Yu Yeh, Yu-Rou Lin, Tze-You Wu, Alexa Escobar Pastor, Danny Danilo Zul, Yun-Chien Hsu, Kuan-Yo Wu, Ke-Fang Liu, Reiji Kannagi, Jang-Yi Chen, Bi-He Cai
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2023-04-01
Серии:	Biomedicines
Предметы:	p53 PTC124 nonsense mutation PTC readthrough site-directed mutagenesis
Online-ссылка:	https://www.mdpi.com/2227-9059/11/5/1310
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