Advances in therapeutic use of a drug-stimulated translational readthrough of premature termination codons
Abstract Premature termination codons (PTCs) in the coding regions of mRNA lead to the incorrect termination of translation and generation of non-functional, truncated proteins. Translational readthrough of PTCs induced by pharmaceutical compounds is a promising way of restoring functional protein e...
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| Principais autores: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BMC
2018-05-01
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| Serier: | Molecular Medicine |
| Fag: | |
| Online adgang: | http://link.springer.com/article/10.1186/s10020-018-0024-7 |
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