QR Code

Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling

Summary: Succinate functions both as a classical TCA cycle metabolite and an extracellular metabolic stress signal sensed by the mainly Gi-coupled succinate receptor SUCNR1. In the present study, we characterize and compare effects and signaling pathways activated by succinate and both classes of no...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Mette Trauelsen, Thomas K. Hiron, Da Lin, Jacob E. Petersen, Billy Breton, Anna Sofie Husted, Siv A. Hjorth, Asuka Inoue, Thomas M. Frimurer, Michel Bouvier, Chris A. O’Callaghan, Thue W. Schwartz
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2021-06-01
Rangatū:Cell Reports
Ngā marau:
GPR91
SUCNR1
succinate
M2 macrophages
G protein
Gq signaling
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S2211124721006112
Ngā Tūtohu: Tāpirihia he Tūtohu
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!

Ngā tūemi rite