Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling

Summary: Succinate functions both as a classical TCA cycle metabolite and an extracellular metabolic stress signal sensed by the mainly Gi-coupled succinate receptor SUCNR1. In the present study, we characterize and compare effects and signaling pathways activated by succinate and both classes of no...

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Autori principali:	Mette Trauelsen, Thomas K. Hiron, Da Lin, Jacob E. Petersen, Billy Breton, Anna Sofie Husted, Siv A. Hjorth, Asuka Inoue, Thomas M. Frimurer, Michel Bouvier, Chris A. O’Callaghan, Thue W. Schwartz
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2021-06-01
Serie:	Cell Reports
Soggetti:	GPR91 SUCNR1 succinate M2 macrophages G protein Gq signaling
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2211124721006112
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