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Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling

Summary: Succinate functions both as a classical TCA cycle metabolite and an extracellular metabolic stress signal sensed by the mainly Gi-coupled succinate receptor SUCNR1. In the present study, we characterize and compare effects and signaling pathways activated by succinate and both classes of no...

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Principais autores: Mette Trauelsen, Thomas K. Hiron, Da Lin, Jacob E. Petersen, Billy Breton, Anna Sofie Husted, Siv A. Hjorth, Asuka Inoue, Thomas M. Frimurer, Michel Bouvier, Chris A. O’Callaghan, Thue W. Schwartz
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021-06-01
Serier:Cell Reports
Fag:
GPR91
SUCNR1
succinate
M2 macrophages
G protein
Gq signaling
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124721006112
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