Dynamics of antigen presentation to transgene product-specific CD4+ T cells and of Treg induction upon hepatic AAV gene transfer

The tolerogenic hepatic microenvironment impedes clearance of viral infections but is an advantage in viral vector gene transfer, which often results in immune tolerance induction to transgene products. Although the underlying tolerance mechanism has been extensively studied, our understanding of an...

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Hlavní autoři:	George Q Perrin, Irene Zolotukhin, Alexandra Sherman, Moanaro Biswas, Ype P de Jong, Cox Terhorst, Andrew M Davidoff, Roland W Herzog
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2016-01-01
Edice:	Molecular Therapy: Methods & Clinical Development
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2329050117300104
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