Immune Response Mechanisms against AAV Vectors in Animal Models

Early preclinical studies in rodents and other species did not reveal that vector or transgene immunity would present a significant hurdle for sustained gene expression. While there was early evidence of mild immune responses to adeno-associated virus (AAV) in preclinical studies, it was generally b...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Ashley T. Martino, David M. Markusic
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2020-06-01
Цуврал:	Molecular Therapy: Methods & Clinical Development
Нөхцлүүд:	adeno-associated virus AAV innate immunity adaptive immunity gene therapy neutralizing antibodies
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S2329050119301573
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!