Optimized AAV rh.10 Vectors That Partially Evade Neutralizing Antibodies during Hepatic Gene Transfer

Of the 12 common serotypes used for gene delivery applications, Adeno-associated virus (AAV)rh.10 serotype has shown sustained hepatic transduction and has the lowest seropositivity in humans. We have evaluated if further modifications to AAVrh.10 at its phosphodegron like regions or predicted immun...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Ruchita Selot, Sathyathithan Arumugam, Bertin Mary, Sabna Cheemadan, Giridhara R. Jayandharan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2017-07-01
coleção:	Frontiers in Pharmacology
Assuntos:	AAV gene therapy immune-escape neutralizing antibody T-cell B-cell
Acesso em linha:	http://journal.frontiersin.org/article/10.3389/fphar.2017.00441/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!