Dynamics of antigen presentation to transgene product-specific CD4+ T cells and of Treg induction upon hepatic AAV gene transfer

The tolerogenic hepatic microenvironment impedes clearance of viral infections but is an advantage in viral vector gene transfer, which often results in immune tolerance induction to transgene products. Although the underlying tolerance mechanism has been extensively studied, our understanding of an...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	George Q Perrin, Irene Zolotukhin, Alexandra Sherman, Moanaro Biswas, Ype P de Jong, Cox Terhorst, Andrew M Davidoff, Roland W Herzog
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2016-01-01
Schriftenreihe:	Molecular Therapy: Methods & Clinical Development
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2329050117300104
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!