MAGEC2 promotes tumorigenesis in multiple myeloma through USP16-mediated deubiquitination and stabilization of c-Myc

Abstract Multiple myeloma (MM) is an incurable malignancy characterized by clonal plasma cell proliferation, in which dysregulated ubiquitination plays a key pathogenic role. Using bufalin as a molecular probe, we identified melanoma-associated antigen C2 (MAGEC2) as a direct binding target and inve...

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Үндсэн зохиолчид:	Zihao Liu, Tingting Hu, Jie Min, Chen Wang, Yuhao Cao, Mengjie Guo, Jinjun Qian, Chunyan Gu, Ye Yang
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2026-06-01
Цуврал:	Experimental Hematology & Oncology
Нөхцлүүд:	Multiple myeloma MAGEC2 USP16 c-Myc Ubiquitination
Онлайн хандалт:	https://doi.org/10.1186/s40164-026-00782-4
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!