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MAGEC2 promotes tumorigenesis in multiple myeloma through USP16-mediated deubiquitination and stabilization of c-Myc

Abstract Multiple myeloma (MM) is an incurable malignancy characterized by clonal plasma cell proliferation, in which dysregulated ubiquitination plays a key pathogenic role. Using bufalin as a molecular probe, we identified melanoma-associated antigen C2 (MAGEC2) as a direct binding target and inve...

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Main Authors: Zihao Liu, Tingting Hu, Jie Min, Chen Wang, Yuhao Cao, Mengjie Guo, Jinjun Qian, Chunyan Gu, Ye Yang
Format: Artigo
Language:Inglês
Published: BMC 2026-06-01
Series:Experimental Hematology & Oncology
Subjects:
Multiple myeloma
MAGEC2
USP16
c-Myc
Ubiquitination
Online Access:https://doi.org/10.1186/s40164-026-00782-4
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