MAGEC2 promotes tumorigenesis in multiple myeloma through USP16-mediated deubiquitination and stabilization of c-Myc

Abstract Multiple myeloma (MM) is an incurable malignancy characterized by clonal plasma cell proliferation, in which dysregulated ubiquitination plays a key pathogenic role. Using bufalin as a molecular probe, we identified melanoma-associated antigen C2 (MAGEC2) as a direct binding target and inve...

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Autors principals:	Zihao Liu, Tingting Hu, Jie Min, Chen Wang, Yuhao Cao, Mengjie Guo, Jinjun Qian, Chunyan Gu, Ye Yang
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-06-01
Col·lecció:	Experimental Hematology & Oncology
Matèries:	Multiple myeloma MAGEC2 USP16 c-Myc Ubiquitination
Accés en línia:	https://doi.org/10.1186/s40164-026-00782-4
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