Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2

Abstract Inhibition of Mycobacterium tuberculosis (Mtb) cell wall assembly is an established strategy for anti-TB chemotherapy. Arabinosyltransferase EmbB, which catalyzes the transfer of arabinose from the donor decaprenyl-phosphate-arabinose (DPA) to its arabinosyl acceptor is an essential enzyme...

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Auteurs principaux:	Lu Zhang, Yao Zhao, Ruogu Gao, Jun Li, Xiuna Yang, Yan Gao, Wei Zhao, Sudagar S. Gurcha, Natacha Veerapen, Sarah M. Batt, Kajelle Kaur Besra, Wenqing Xu, Lijun Bi, Xian’en Zhang, Luke W. Guddat, Haitao Yang, Quan Wang, Gurdyal S. Besra, Zihe Rao
Format:	Artigo
Langue:	Inglês
Publié:	Oxford University Press 2020-05-01
Collection:	Protein & Cell
Sujets:	Mycobacterium tuberculosis EmbB cryo-EM ethambutol cell wall synthesis arabinoglacatan
Accès en ligne:	https://doi.org/10.1007/s13238-020-00726-6
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