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Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2

Abstract Inhibition of Mycobacterium tuberculosis (Mtb) cell wall assembly is an established strategy for anti-TB chemotherapy. Arabinosyltransferase EmbB, which catalyzes the transfer of arabinose from the donor decaprenyl-phosphate-arabinose (DPA) to its arabinosyl acceptor is an essential enzyme...

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Kaydedildi:
Asıl Yazarlar: Lu Zhang, Yao Zhao, Ruogu Gao, Jun Li, Xiuna Yang, Yan Gao, Wei Zhao, Sudagar S. Gurcha, Natacha Veerapen, Sarah M. Batt, Kajelle Kaur Besra, Wenqing Xu, Lijun Bi, Xian’en Zhang, Luke W. Guddat, Haitao Yang, Quan Wang, Gurdyal S. Besra, Zihe Rao
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2020-05-01
Seri Bilgileri:Protein & Cell
Konular:
Mycobacterium tuberculosis
EmbB
cryo-EM
ethambutol
cell wall synthesis
arabinoglacatan
Online Erişim:https://doi.org/10.1007/s13238-020-00726-6
Etiketler: Etiketle
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