Competition for the nascent leading strand shapes the requirements for PCNA loading in the replisome
Abstract During DNA replication, the DNA polymerases Pol δ and Pol ε utilise the ring-shaped sliding clamp PCNA to enhance their processivity. PCNA loading onto DNA is accomplished by the clamp loaders RFC and Ctf18-RFC, which function primarily on the lagging and the leading strand, respectively. R...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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Springer Nature
2025-02-01
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| Schriftenreihe: | The EMBO Journal |
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| Online-Zugang: | https://doi.org/10.1038/s44318-025-00386-4 |
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