CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold
The eukaryotic replisome assembles around the CMG helicase, which stably associates with DNA replication forks throughout elongation. When replication terminates, CMG is ubiquitylated on its Mcm7 subunit and disassembled by the Cdc48/p97 ATPase. Until now, the regulation that restricts CMG ubiquityl...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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eLife Sciences Publications Ltd
2020-08-01
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| Schriftenreihe: | eLife |
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| Online-Zugang: | https://elifesciences.org/articles/60371 |
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