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The Response of the Replication Apparatus to Leading Template Strand Blocks

Duplication of the genome requires the replication apparatus to overcome a variety of impediments, including covalent DNA adducts, the most challenging of which is on the leading template strand. Replisomes consist of two functional units, a helicase to unwind DNA and polymerases to synthesize it. T...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Hauptverfasser: Marina A. Bellani, Althaf Shaik, Ishani Majumdar, Chen Ling, Michael M. Seidman
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2023-11-01
Schriftenreihe:Cells
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Online-Zugang:https://www.mdpi.com/2073-4409/12/22/2607
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