Cell passage number drives transcriptomic drift as an overlooked factor in experimental reproducibility
Abstract The reproducibility of scientific research has been increasingly challenged in recent years. While extrinsic factors (e.g., cross-contamination, mycoplasma infection, serum variability) are well-studied, the role of intrinsic attributes like cell passage number remains underexplored. Using...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
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Nature Portfolio
2025-11-01
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| Colecção: | Scientific Reports |
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| Acesso em linha: | https://doi.org/10.1038/s41598-025-29424-1 |
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