Cell passage number drives transcriptomic drift as an overlooked factor in experimental reproducibility

Abstract The reproducibility of scientific research has been increasingly challenged in recent years. While extrinsic factors (e.g., cross-contamination, mycoplasma infection, serum variability) are well-studied, the role of intrinsic attributes like cell passage number remains underexplored. Using...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Shuai Liu, Hailun Peng, Junyan Meng, Liyuan Zhuo, Shaoping Fu, Wei Yang
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Nature Portfolio 2025-11-01
Sarja:	Scientific Reports
Aiheet:	Cell passage Reproducibility Cell culture
Linkit:	https://doi.org/10.1038/s41598-025-29424-1
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