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Sonic Hedgehog Signaling in Cranial Neural Crest Cells Regulates Microvascular Morphogenesis in Facial Development

Sonic hedgehog (Shh) pathway disruption causes craniofacial malformations including orofacial clefts (OFCs) of the lip and palate. In normal craniofacial morphogenesis, Shh signals to multipotent cranial neural crest cells (cNCCs) and was recently discovered to regulate the angiogenic transcriptome,...

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Principais autores: Miranda R. Sun, Hannah M. Chung, Veronika Matsuk, Dustin M. Fink, Matthew J. Stebbins, Sean P. Palecek, Eric V. Shusta, Robert J. Lipinski
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-10-01
Serier:Frontiers in Cell and Developmental Biology
Fag:
perivascular
pericyte
cranial neural crest
Sonic hedgehog
orofacial clefting
microvascular morphogenesis
Online adgang:https://www.frontiersin.org/article/10.3389/fcell.2020.590539/full
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