Proinflammatory pathways contribute to the pathogenesis of Clostridioides difficile infection in a murine model using Spatial transcriptomics

Abstract Clostridioides difficile (C. difficile) is a common cause of antibiotic-induced diarrhea and causes the highest number of nosocomial infections. Only two antibiotics are currently recommended for treating C. difficile infection (CDI), which may contribute to unsatisfactory treatment outcome...

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Main Authors: Niloufar Ghahari, Sanjeev Narayanan, Ahmed AbdelKhalek, Deepti Pillai
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Portfolio 2025-10-01
Sraith:Scientific Reports
Ábhair:
Clostridioides difficile
CDI
Gene expression
Spatial transcriptomics
IL-17
NF-κB
Rochtain Ar Líne:https://doi.org/10.1038/s41598-025-19106-3
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