Proinflammatory pathways contribute to the pathogenesis of Clostridioides difficile infection in a murine model using Spatial transcriptomics

Abstract Clostridioides difficile (C. difficile) is a common cause of antibiotic-induced diarrhea and causes the highest number of nosocomial infections. Only two antibiotics are currently recommended for treating C. difficile infection (CDI), which may contribute to unsatisfactory treatment outcome...

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Detalhes bibliográficos
Main Authors: Niloufar Ghahari, Sanjeev Narayanan, Ahmed AbdelKhalek, Deepti Pillai
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2025-10-01
Colecção:Scientific Reports
Assuntos:
Clostridioides difficile
CDI
Gene expression
Spatial transcriptomics
IL-17
NF-κB
Acesso em linha:https://doi.org/10.1038/s41598-025-19106-3
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