Proinflammatory pathways contribute to the pathogenesis of Clostridioides difficile infection in a murine model using Spatial transcriptomics

Abstract Clostridioides difficile (C. difficile) is a common cause of antibiotic-induced diarrhea and causes the highest number of nosocomial infections. Only two antibiotics are currently recommended for treating C. difficile infection (CDI), which may contribute to unsatisfactory treatment outcome...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Niloufar Ghahari, Sanjeev Narayanan, Ahmed AbdelKhalek, Deepti Pillai
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Portfolio 2025-10-01
Saila:Scientific Reports
Gaiak:
Clostridioides difficile
CDI
Gene expression
Spatial transcriptomics
IL-17
NF-κB
Sarrera elektronikoa:https://doi.org/10.1038/s41598-025-19106-3
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