MIF functional polymorphisms are associated with acute GVHD progression and steroid-refractoriness

IntroductionApproximately 50% of allogeneic hematopoietic stem cell transplantation (HSCT) Q6 recipients develop graft versus host disease (GVHD). Glucocorticoids (GC) are the first line of treatment for both acute and chronic GVHD. Failure to respond to GC [steroid-refractory (SR)] encompasses a ve...

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Главные авторы:	Aviran Aharon, Batia Avni, Daniel Louzoun, Shlomo Elias, Polina Stepensky, Ron Ram, Tsila Zuckerman, Roberto Meza-Romero, Arthur A. Vandenbark, Sigal Grisariu, Gil Benedek
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2025-04-01
Серии:	Frontiers in Immunology
Предметы:	MIF acute GVHD steroid-refractory HSCT polymorphism
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1504976/full
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