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Tissue nonspecific and intestinal alkaline phosphatase crosstalk: a missing link in hypophosphatasia pathophysiology?

Abstract Background Tissue-nonspecific alkaline phosphatase (TNSALP) and intestinal alkaline phosphatase (IAP) are functionally similar enzymes, but their relationship in hypophosphatasia (HPP) remains unexplored. This study investigated the impact of HPP—a condition caused by ALPL gene mutations th...

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Principais autores: Luis Martínez-Heredia, Trinidad González-Cejudo, María Carmen Andreo-López, Victoria Contreras-Bolívar, Cristina García-Fontana, Beatriz García-Fontana, Manuel Muñoz-Torres
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-02-01
Serier:Journal of Translational Medicine
Fag:
TNSALP
IAP
Hypophosphatasia
Inflammation
Gut
Serum
Online adgang:https://doi.org/10.1186/s12967-026-07791-1
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