Tissue nonspecific and intestinal alkaline phosphatase crosstalk: a missing link in hypophosphatasia pathophysiology?

Abstract Background Tissue-nonspecific alkaline phosphatase (TNSALP) and intestinal alkaline phosphatase (IAP) are functionally similar enzymes, but their relationship in hypophosphatasia (HPP) remains unexplored. This study investigated the impact of HPP—a condition caused by ALPL gene mutations th...

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Bibliografische Detailangaben

Hauptverfasser:	Luis Martínez-Heredia, Trinidad González-Cejudo, María Carmen Andreo-López, Victoria Contreras-Bolívar, Cristina García-Fontana, Beatriz García-Fontana, Manuel Muñoz-Torres
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-02-01
Schriftenreihe:	Journal of Translational Medicine
Schlagworte:	TNSALP IAP Hypophosphatasia Inflammation Gut Serum
Online-Zugang:	https://doi.org/10.1186/s12967-026-07791-1
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