Causal neurodevelopmental origins of scoliosis: Multi-omics Mendelian randomization reveals brain–region–specific pathways and protein mediators

Background: The causal relationship between early-life central nervous system (CNS) infections and adolescent idiopathic scoliosis (AIS) remains unresolved, with limited evidence on mediating mechanisms linking neuroanatomical changes to spinal deformity. Method: Through three longitudinal cohorts (...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Shuhao Zhang, Sisi Lu, Shiyu Chen, Xiangxiang Pan, Dongdong Xia, Lue Liu, Chenglong Xie, Majid Nisar, Aimin Wu, Xiaolei Zhang, Xiangyang Wang, Chongan Huang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-01-01
coleção:	Journal of Orthopaedic Translation
Assuntos:	Imaging-derived phenotypes Mendelian randomisation Retrospective cohort study Scoliosis UK Biobank Viral encephalitis
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2214031X25001615
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!