Causal neurodevelopmental origins of scoliosis: Multi-omics Mendelian randomization reveals brain–region–specific pathways and protein mediators

Background: The causal relationship between early-life central nervous system (CNS) infections and adolescent idiopathic scoliosis (AIS) remains unresolved, with limited evidence on mediating mechanisms linking neuroanatomical changes to spinal deformity. Method: Through three longitudinal cohorts (...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Shuhao Zhang, Sisi Lu, Shiyu Chen, Xiangxiang Pan, Dongdong Xia, Lue Liu, Chenglong Xie, Majid Nisar, Aimin Wu, Xiaolei Zhang, Xiangyang Wang, Chongan Huang
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2026-01-01
Цуврал:	Journal of Orthopaedic Translation
Нөхцлүүд:	Imaging-derived phenotypes Mendelian randomisation Retrospective cohort study Scoliosis UK Biobank Viral encephalitis
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S2214031X25001615
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!